Poultry USA - February 2020 - 12

12 ❙ WATTPoultryUSA

Could avian flu-resistant chickens
be a commercial reality?
The first gene-edited chickens resistant to avian influenza could be
ready for production within three to five years, but global regulations
need to catch up with the technology.
JENNY HONE

M

ike McGrew, senior lecturer at The
Roslin Institute at the University of
Edinburgh, Scotland, U.K., talked
to Jenny Hone about the encouraging research
they are conducting into preventing the spread
of the deadly bird flu virus (avian influenza)
in poultry and the regulatory minefield facing
gene-edited animals worldwide.

Hone: When did you start looking
at the possibility of gene editing
in poultry to prevent the spread of
bird flu? 
McGrew: Helen Sang's group
at The Roslin Institute developed
transgenic chickens in 2011 in
collaboration with Dr. Laurence
Tiley at Cambridge University.
These transgenic chickens, while
susceptible to avian influenza, did
not transmit the virus to co-housed
Mike McGrew
chickens in the same pen. Since
Courtesy University of Edinburgh
that time, the goal of researchers
has been to find genetic targets
that can be subtly modified to render the
chicken resistant to avian influenza. Working
with our collaborators, including Professor
Wendy Barclay and Dr. Jason Long at Imperial
College London, we believe we have now identified one of these targets.

Hone: How are these targets
modified?
McGrew: The flu virus depends on cellular
proteins to replicate and, therefore, spread from
one bird to another. Avian influenza uses a
cellular protein called ANP32A (Acidic Nuclear
Phosphoprotein 32 Family Member A) to replicate. We discovered that to do this the virus uses
a particular part of the ANP32A protein and,
more specifically, it needs to interact with a very

The first genome-edited chicks
should hatch during the first half
of 2020. Bazil8 | Bigstock.com
www.WATTAgNet.com ❙ February 2020


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Poultry USA - February 2020

Table of Contents for the Digital Edition of Poultry USA - February 2020

Poultry USA - February 2020
Contents
Popeyes’ chicken sandwich is great! Will people switch?
McDonald’s launches new bid to compete in chicken sandwich wars
Could avian flu-resistant chickens be a commercial reality?
Digital technology could streamline the poultry supply chain
ASF drives global poultry market in 2020
Could deboning machinery beat a skilled worker?
How to ensure a clean water supply in the broiler house
Woody breast discovery could offer options for control
Prevention, risk minimization keep foreign materials out
Dark meat is chicken’s next growth engine
Consumers still want value, convenience and flavor
What feed formulators need to know about organic rations
Midwest Poultry Federation Convention 2020: Poultry’s future
Product Review
Market Place
Ad Index
Poultry USA - February 2020 - CT1
Poultry USA - February 2020 - CT2
Poultry USA - February 2020 - Poultry USA - February 2020
Poultry USA - February 2020 - Cover2
Poultry USA - February 2020 - Contents
Poultry USA - February 2020 - Popeyes’ chicken sandwich is great! Will people switch?
Poultry USA - February 2020 - 3
Poultry USA - February 2020 - 4
Poultry USA - February 2020 - 5
Poultry USA - February 2020 - McDonald’s launches new bid to compete in chicken sandwich wars
Poultry USA - February 2020 - 7
Poultry USA - February 2020 - 8
Poultry USA - February 2020 - 9
Poultry USA - February 2020 - 10
Poultry USA - February 2020 - 11
Poultry USA - February 2020 - Could avian flu-resistant chickens be a commercial reality?
Poultry USA - February 2020 - 13
Poultry USA - February 2020 - 14
Poultry USA - February 2020 - 15
Poultry USA - February 2020 - Digital technology could streamline the poultry supply chain
Poultry USA - February 2020 - 17
Poultry USA - February 2020 - ASF drives global poultry market in 2020
Poultry USA - February 2020 - 19
Poultry USA - February 2020 - 20
Poultry USA - February 2020 - 21
Poultry USA - February 2020 - Could deboning machinery beat a skilled worker?
Poultry USA - February 2020 - 23
Poultry USA - February 2020 - How to ensure a clean water supply in the broiler house
Poultry USA - February 2020 - 25
Poultry USA - February 2020 - 26
Poultry USA - February 2020 - 27
Poultry USA - February 2020 - Woody breast discovery could offer options for control
Poultry USA - February 2020 - 29
Poultry USA - February 2020 - Prevention, risk minimization keep foreign materials out
Poultry USA - February 2020 - 31
Poultry USA - February 2020 - 32
Poultry USA - February 2020 - 33
Poultry USA - February 2020 - 34
Poultry USA - February 2020 - 35
Poultry USA - February 2020 - Dark meat is chicken’s next growth engine
Poultry USA - February 2020 - 37
Poultry USA - February 2020 - 38
Poultry USA - February 2020 - 39
Poultry USA - February 2020 - 40
Poultry USA - February 2020 - 41
Poultry USA - February 2020 - Consumers still want value, convenience and flavor
Poultry USA - February 2020 - 43
Poultry USA - February 2020 - 44
Poultry USA - February 2020 - 45
Poultry USA - February 2020 - What feed formulators need to know about organic rations
Poultry USA - February 2020 - 47
Poultry USA - February 2020 - 48
Poultry USA - February 2020 - 49
Poultry USA - February 2020 - Midwest Poultry Federation Convention 2020: Poultry’s future
Poultry USA - February 2020 - Product Review
Poultry USA - February 2020 - Ad Index
Poultry USA - February 2020 - Cover3
Poultry USA - February 2020 - Cover4
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